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Niraparib
CAS NO:1038915-60-4
Key Words:(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide hydrocholoride;Niraparib (MK-4827)

Molecular Formula:  C19H20N4O

Molecular Weight:  320.3883

Density:1.34

Purity: ≥98

Description

It has been recently approved by FDA for the maintenance treatment of adult patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in complete or partial response to platinum-based chemotherapy. In vitro studies have shown that niraparib-induced cytotoxicity may involve inhibition of PARP enzymatic activity and increased formation of PARP-DNA complexes resulting in DNA damage, apoptosis and cell death.


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