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Liraglutide
CAS NO:204656-20-2
Key Words:Liraglutidum [inn-latin]

Molecular Formula:  C172H265N43O51

Molecular Weight:  3751.20000

Purity: ≥99

Description

Liraglutide is a long-acting GLP-1 analog, designed to bind to albumin as the main molecular mechanism of protraction[1-4]. In vitro, this was shown in the receptor cAMP as well as binding assay where addition of albumin shifted the dose-response and/or binding curve to the right. The apparent reduced potency of liraglutide underlines that only the free fraction of liraglutide is responsible for its pharmacological effect in vitro as well as in vivo. Furthermore, liraglutide in a pharmaceutical solution forms a micell-like heptamer that may contribute to the slow absorption from the subcutis[1-4].

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