Sacubitril valsartan sodium is a dual-acting angiotensin receptor-neprilysin inhibitor (ARNI) with a unique mode of action that reduces strain on the failing heart. It enhances the body's natural defenses against heart failure by increasing levels of natriuretic peptides and other endogenous vasoactive peptides, while simultaneously inhibiting the renin-angiotensin-aldosterone system (RAAS).