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/ Home / Product Center / Advance Intermediates / Anti-Cancer /

Trametinib Intermediate

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Anti-Diabetes & Weight Loss Anti-Cancer Series Anti-Virus Series Others

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N-(3-(3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,7,8-tetrahydropyrido[2,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide
CAS
871700-17-3
MF
C26H23FIN5O4
MW
615.39
Purity
98%

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Indication
Trametinib Intermediate
Description

Trametinib is an inhibitor of MEK1 and -2. It inhibits B-RAF- and C-RAF-induced phosphorylation of MEK1 (IC50s = 3.4 and 1.8 nM, respectively) and MEK2 (IC50s = 1.6 and 0.92 nM, respectively).