Linaclotide, a synthetic peptide structure containing 14 amino acids related to the endogenous guanosine peptide family, is the only FDA-approved clinically available intestinal topical-acting GC-ChemicalbookC (guanylate cyclase-C) agonist analog for the treatment of constipated irritable bowel syndrome (IBS-C) and chronic idiopathic constipation (CIC ) in adult patients
