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How to choose between semaglutide and tirzepatide

How to choose between semaglutide and tirzepatide

Release Time: 2024-09-06

News Source: SenovaTech

Author: SENOVA—Lucas

Tirzepatide costs

Mounjaro 5 mg/0.5 mL subcutaneous injection: $1135 per one month supply

Zepbound 5 mg/0.5 mL subcutaneous injection: $1125 per month supply

Semaglutide costs

Ozempic 2 mg/3 mL subcutaneous injection: $1029 per month supply

Wegovy 2.4 mg/3 mL subcutaneous injection: $1430 per month supply

Rybelsus 7 mg oral tablet: $1,029 for a one month supply of 30 tablets

How to choose between semaglutide and tirzepatide(图1)

CNT was calculated by multiplying drug costs (from a common US drug discount website) by follow-up time and dividing it the average weight reduction percentage for each drug vs. placebo.

Results showed that tirzepatide led to a weight loss of 17.8% compared to 12.4% for semaglutide.

The total cost of 72 weeks of tirzepatide treatment was estimated to be about $17,500 compared to $22,800 for 68 weeks of semaglutide.

Overall, the cost to treat each 1% reduction of body weight was $985 with tirzepatide and $1845 with semaglutide.

Semaglutide-VS-Tirzepatide.jpg

Which should I use - tirzepatide or semaglutide?

In the class of incretin mimetics, factors like risk of severe heart disease, heart disease history (former heart attack or stroke), A1C and weight loss needs, costs and insurance coverage, and patient preference are all important considerations when determining which drug to use.

You and your healthcare provider should consider your individual needs when selecting a treatment for type 2 diabetes or weight loss. What may be the best treatment for others may not be the best for you. You might think about:

Heart risk factors: Semaglutide (Ozempic and Wegovy) have been shown to reduce cardiovascular risks like heart attack, stroke and heart-related death in patients with established heart disease. Cardiovascular outcomes studies for tirzepatide are still ongoing.

Side effects: Studies have shown tirzepatide may have a greater effect on weight loss and A1C levels, but higher doses of tirzepatide are also linked to more severe stomach side effects like nausea, vomiting and diarrhea.

Dosage form: Most of these products are available as injections. If you prefer not to use an injection for treatment of type 2 diabetes, Rybelsus is an oral form of semaglutide that is taken by mouth once daily.

Use in children: All semaglutide and tirzepatide products are approved for use in adults. At this time, only Wegovy is approved for weight loss in children 12 years and older.

Affordability: Cash costs and insurance coverage are important considerations. Many insurance companies will not cover the costs of these medications, especially for weight loss. Check with your insurance before you decide on a treatment with your healthcare provider. More affordable options may be available.